Steroid-sensitive mechanism of soluble immune response suppressor production in steroid-responsive nephrotic syndrome.
نویسندگان
چکیده
منابع مشابه
Steroid-sensitive mechanism of soluble immune response suppressor production in steroid-responsive nephrotic syndrome.
Soluble immune response suppressor (SIRS), a lymphokine that suppresses antibody production and delayed type hypersensitivity in vivo, has been detected in urine and serum from certain patients with nephrotic syndrome. In the present paper, the relationship between SIRS production and nephrotic syndrome is further characterized. A striking correlation was found between detection of SIRS and the...
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Cyclophosphamide has been shown to be effective in preventing relapse of steroid-responsive nephrotic syndrome of childhood (Barratt and Soothill, 1970). However, a similar significant effect was not observed by Abramowicz et al. (1970), in a doubleblind trial of azathioprine. This drug was administered in a dosage of 60 mg/M2 surface area per day for 6 months to steroid-responsive nephrotic ch...
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Nephrotic Syndrome (NS) is one of the most frequent glomerular diseases seen in children. Children who go into complete remissin following treatment with corticosteroids are classified as having “steroid sensitive” NS. In developed countries over 80% of children with idiopathic NS have steroid sensitive disease although response to steroids is somewhat tempered in developing countries, especial...
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OBJECTIVE To review the disease course in patients with steroid sensitive nephrotic syndrome (SSNS) and the factors that determine outcome DESIGN Retrospective, analytical SETTING Pediatric Nephrology Clinic at referral center in North India PARTICIPANTS/PATIENTS All patients with SSNS evaluated between 1990 and 2005 INTERVENTION: None MAIN OUTCOME MEASURES Disease course, in patients w...
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The objective of this study was to identify predictors of relapse and determine the predictive score for relapse in steroid-sensitive nephrotic syndrome. Ninety-nine children with nephrotic syndrome visiting the pediatric nephrology outpatient clinic of Soetomo Hospital from 1983 to 2001 were studied. There were 63 children with relapses (50 infrequent relapses, 13 frequent relapses) and 36 chi...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1987
ISSN: 0021-9738
DOI: 10.1172/jci112792